Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis

Blood. 1991 Jun 1;77(11):2441-4.


A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Base Sequence
  • Blast Crisis / genetics*
  • Chromosome Deletion
  • DNA / blood
  • DNA / genetics
  • DNA / isolation & purification
  • Exons
  • Gene Rearrangement
  • Humans
  • Introns
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology
  • Male
  • Molecular Sequence Data
  • Mutation*
  • Polymerase Chain Reaction / methods
  • Tumor Suppressor Protein p53 / genetics*


  • Tumor Suppressor Protein p53
  • DNA