Use of platelet rich plasma to treat plantar fasciitis: design of a multi centre randomized controlled trial

BMC Musculoskelet Disord. 2010 Apr 14;11:69. doi: 10.1186/1471-2474-11-69.


Background: If conservative treatment for chronic plantar fasciitis fails, often a corticosteroid injection is given. Corticosteroid injection gives temporarily pain reduction, but no healing. Blood platelets initiate the natural healing rate. GPS(R) gives an eightfold concentrate platelets of patients own blood. Injection of these platelets in the attachment of the fascia to the os calcis might induce a healing rate.

Methods and design: A randomized controlled multi centre trial will be performed. The study population consists of 120 patients of 18 years and older. Patients with chronic plantar fasciitis will be allocated randomly to have a steroid injection or an autologous platelet concentrate injections. Data will be collected before the procedure, 4,8,12,26 weeks and 1 year after the procedure.The main outcome measures of this study are pain and function measured with questionnaires.

Conclusion: Recent literature show positive effects for the treatment of tendinosis with autologous platelet injections. The forthcoming trial will compare treatment for chronic plantar fasciitis with a steroid injection versus an autologous platelet injection. Our results will be published as soon as they become available.

Trial registration number: NCT00758641.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / administration & dosage
  • Adult
  • Aged
  • Anesthetics, Local / administration & dosage
  • Clinical Protocols
  • Clinical Trials as Topic / methods
  • Disability Evaluation
  • Fasciitis, Plantar / physiopathology
  • Fasciitis, Plantar / therapy*
  • Humans
  • Middle Aged
  • Netherlands
  • Outcome Assessment, Health Care / methods
  • Pain Measurement / methods
  • Patient Satisfaction
  • Platelet Transfusion / methods*
  • Platelet-Rich Plasma / physiology*
  • Quality of Life
  • Research Design
  • Surveys and Questionnaires
  • Transplantation, Autologous / methods
  • Wound Healing / physiology*
  • Young Adult


  • Adrenal Cortex Hormones
  • Anesthetics, Local

Associated data