Abstract
We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-alpha, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-alpha, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-alpha, nitrite, inducible nitric oxide synthase expression, and nuclear factor-kappaB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.
2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Lung Injury / chemically induced
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Acute Lung Injury / pathology
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Acute Lung Injury / prevention & control*
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Animals
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Benzodioxoles / pharmacology*
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Blotting, Western
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Bronchoalveolar Lavage Fluid / cytology
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Endotoxemia / pathology
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Endotoxemia / prevention & control*
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / toxicity
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Macrophages, Alveolar / drug effects
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Male
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NF-kappa B / metabolism
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Nitric Oxide Synthase Type II / biosynthesis
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Nitric Oxide Synthase Type II / metabolism
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Nitrites / metabolism
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Phenols / pharmacology*
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Pneumonia / chemically induced
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Pneumonia / pathology
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Pneumonia / prevention & control*
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Pulmonary Alveoli / pathology
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Pulmonary Edema / chemically induced
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Pulmonary Edema / pathology
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RNA, Messenger / biosynthesis
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Rats
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Rats, Sprague-Dawley
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Benzodioxoles
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Lipopolysaccharides
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NF-kappa B
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Nitrites
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Phenols
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RNA, Messenger
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Tumor Necrosis Factor-alpha
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sesamol
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Nitric Oxide Synthase Type II