Effects of a reduced nitrogen diet on calcitriol levels and calcium metabolism in growing goats

Abstract

For monogastric animals, changes in dietary protein content modulate calcium (Ca) metabolism by changing parathyroid hormone and calcitriol concentrations. However, the effects of dietary nitrogen (N) restriction on Ca metabolism are not known in ruminants. Since ruminants express endogenous recycling mechanisms very efficiently to save N, it is known that these recycling mechanisms protect ruminants against N depletion in times of dietary N restriction. Therefore, consequences on Ca metabolism induced by reduction of dietary N supply as observed in monogastric animals should not occur in ruminants. Due to this specific metabolic feature, a reduction of dietary N intake can be used to diminish environmental N pollution. The aim of the present study was to determine the consequences of a reduced N intake on Ca homeostasis and respective regulatory hormone concentrations in ruminants. Growing goats fed with a reduced N diet showed a decrease in ionised calcium (Ca2+) and total Ca concentrations while bone resorption marker carboxyterminal cross-linked telopeptide of type I collagen increased in plasma. Unexpectedly, despite hypocalcemia, concentrations of calcitriol were decreased in the animals of the N reduction group whereas calcidiol levels were not affected. From this data, it can be concluded that the Ca metabolism of growing goats can be modulated by changes of dietary N content like in monogastric animals.