Androgen regulation of gene expression

Adv Cancer Res. 2010;107:137-62. doi: 10.1016/S0065-230X(10)07005-3.

Abstract

The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.

Publication types

  • Review

MeSH terms

  • Androgens / genetics
  • Androgens / metabolism*
  • Cell Differentiation
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic*
  • Gene Targeting
  • Humans
  • Lipids / biosynthesis
  • Male
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology
  • Receptors, Androgen / metabolism

Substances

  • Androgens
  • Lipids
  • Receptors, Androgen