Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection

J Cyst Fibros. 2010 Jul;9(4):272-6. doi: 10.1016/j.jcf.2010.03.008. Epub 2010 Apr 18.


Mycobacterium abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with recent treatment for Mycobacterium abscessus lung infection. Despite prolonged antibiotic courses and adjustment of immunosuppressive therapy the first three patients developed skin infection and abscesses. At follow-up after 1, 3, 5 and 7years respectively no patient had evidence of M abscessus infection and all had stable lung function. Lung transplantation in patients with M abscessus lung infection is feasible but may involve severe complications.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Cystic Fibrosis / microbiology*
  • Cystic Fibrosis / surgery*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung Transplantation*
  • Male
  • Mycobacterium Infections / complications*
  • Mycobacterium Infections / drug therapy
  • Recovery of Function
  • Transplantation Conditioning
  • Young Adult


  • Anti-Bacterial Agents