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. 2010 Jul;54(7):3024-6.
doi: 10.1128/AAC.00102-10. Epub 2010 Apr 19.

Exploratory study of the prevalence and clinical significance of tobramycin-mediated biofilm induction in Pseudomonas aeruginosa isolates from cystic fibrosis patients

Danielle Elliott  1 , Jane L Burns, Lucas R Hoffman
Affiliations
Free PMC article

Exploratory study of the prevalence and clinical significance of tobramycin-mediated biofilm induction in Pseudomonas aeruginosa isolates from cystic fibrosis patients

Danielle Elliott et al. Antimicrob Agents Chemother. 2010 Jul.
Free PMC article

Abstract

Exposure to aminoglycoside antibiotics induces biofilm formation by a laboratory strain of the cystic fibrosis (CF) pathogen Pseudomonas aeruginosa. Here, we detected this effect among about half of the clinical isolates from CF patients in a cross-sectional collection, suggesting that biofilm induction may represent a common mechanism of inducible aminoglycoside resistance in CF infections. This induction always occurred at the same tobramycin concentration regardless of MIC, suggesting that the mechanisms of killing and induction may be separable.

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