Molecular mechanisms regulating TGF-beta-induced Foxp3 expression

Mucosal Immunol. 2010 May;3(3):230-8. doi: 10.1038/mi.2010.7. Epub 2010 Mar 10.


Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as perhaps might be predicted by the fact that there is an overarching need of the immune system to finetune response to environmental antigens. In this review we discuss these mechanisms, with the aim of presenting a broad picture of how the various observations fit together to form an integrated regulatory regime.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / immunology
  • Antigens / metabolism
  • Forkhead Transcription Factors / biosynthesis
  • Forkhead Transcription Factors / immunology*
  • Gene Expression Regulation / immunology*
  • Humans
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism
  • Transforming Growth Factor beta / immunology*
  • Transforming Growth Factor beta / metabolism


  • Antigens
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Transforming Growth Factor beta