Drug discovery: engineering drug combinations

Nat Chem Biol. 2010 May;6(5):318-9. doi: 10.1038/nchembio.353.


The level of an individual protein in cells treated with combinations of drugs is best explained by simple linear superposition of the protein levels in response to single drugs. This finding may facilitate rational design of higher order drug combinations.

Publication types

  • Comment
  • News

MeSH terms

  • Drug Discovery*
  • Drug Therapy, Combination
  • HIV Infections / drug therapy
  • Humans
  • Neoplasms / drug therapy