Three new indole alkaloids from Trigonostemon lii

Org Lett. 2010 May 21;12(10):2370-3. doi: 10.1021/ol100715x.

Abstract

Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1-3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC(50) = 0.95 microg/mL, TI = 7.9).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Euphorbiaceae / chemistry*
  • HIV-1 / drug effects
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Plant Leaves / chemistry
  • Stereoisomerism

Substances

  • Anti-HIV Agents
  • Indole Alkaloids
  • trigonoliimine A
  • trigonoliimine B
  • trigonoliimine C