The role of spectral-domain optical coherence tomography in the diagnosis of retinal angiomatous proliferation

Klin Monbl Augenheilkd. 2010 Apr;227(4):309-11. doi: 10.1055/s-0029-1245221. Epub 2010 Apr 20.


Background: We present the findings of spectral-domain optical coherence tomography (OCT) in 8 patients with retinal angiomatous proliferation.

History and signs: Eight patients with a known history of age-related macular degeneration presented with a recent decrease of visual acuity in one eye. On fundus examination, all patients showed an elevated macular lesion associated with intra- or subretinal hemorrhage and retinal hard exudates. Fluorescein and indocyanine-green (ICG) angiography, together with spectral-domain OCT (Optopol Copernicus SOCT), were performed.

Therapy and outcome: Fluorescein angiography showed early hyperfluorescence with late leakage in all cases. A serous pigment epithelium detachment was present in 6 cases. ICG angiography showed a hot spot in the macular area. The OCT showed a serous pigment epithelium detachment in 6 cases and intraretinal cysts in all cases. The line crossing the ICG visible hot spot showed a greatly hyperreflective intraretinal lesion located at various depths inside the retina.

Conclusions: Spectral-domain OCT is a useful complementary tool to confirm the diagnosis of retinal angiomatous proliferation. Its high resolution and speed enables accurate localization of the angiomatous lesion.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angiomatosis / complications*
  • Angiomatosis / pathology*
  • Female
  • Humans
  • Macular Degeneration / complications*
  • Macular Degeneration / pathology*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Retinal Neovascularization / complications*
  • Retinal Neovascularization / pathology*
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / methods*