Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines

Br J Haematol. 2010 Jun;149(5):675-92. doi: 10.1111/j.1365-2141.2010.08161.x. Epub 2010 Apr 16.


A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.

Publication types

  • Practice Guideline
  • Review

MeSH terms

  • Epstein-Barr Virus Infections / complications
  • Humans
  • Lymphoproliferative Disorders / diagnosis*
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / pathology
  • Organ Transplantation / adverse effects*
  • Population Surveillance / methods
  • Postoperative Care / methods
  • Preoperative Care / methods
  • Risk Factors