Contagious Period for Pandemic (H1N1) 2009

Emerg Infect Dis. 2010 May;16(5):783-8. doi: 10.3201/eid1605.091894.

Abstract

We estimated the proportion of persons with pandemic (H1N1) 2009 who were shedding infectious virus at diagnosis and on day 8 of illness. In households with confirmed cases, nasopharyngeal swabs were collected on all members and tested by PCR and virus culture. Of 47 cases confirmed by PCR at &lt7 days of illness, virus culture was positive in 92% (11/12) of febrile and 63% (22/35) of afebrile persons. Of 43 persons with PCR-confirmed pandemic (H1N1) 2009 from whom a second specimen was collected on day 8, 74% remained PCR positive and 19% were culture positive. If the 73 symptomatic household members without PCR-confirmed illness are assumed to have pandemic (H1N1) 2009, a minimum of 8% (6/73) of case-patients shed replicating virus on day 8. Self-isolation only until fever abates appears insufficient to limit transmission. Self-isolation for a week may be more effective, although some case-patients still would shed infectious virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Disease Outbreaks
  • Female
  • Fever / virology
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza, Human / epidemiology
  • Influenza, Human / physiopathology
  • Influenza, Human / transmission*
  • Influenza, Human / virology*
  • Male
  • Nasopharynx / virology
  • Patient Isolation
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification
  • Time Factors
  • Virus Cultivation
  • Virus Shedding

Substances

  • RNA, Viral