Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids

Int J Cosmet Sci. 2010 Apr;32(2):99-106. doi: 10.1111/j.1468-2494.2010.00522.x.


Herbal anti-wrinkle cosmetics were formulated from ginkgo (Ginkgo biloba), a mixture of tea and rooibos (Camellia sinensis and Aspalathus linearis) and soybean (Glycine soja). These extracts were incorporated into the preliminary developed stable gel base with good preference. The gingko formulation was found to be more stable than the formula containing a mixture of tea and rooibos and the soybean formula. Clinical efficacies of the ginkgo formula and the formula containing a mixture of tea and rooibos were compared following 28 days of application. The ginkgo preparation increased skin moisturization (27.88%) and smoothness (4.32%) and reduced roughness (0.4%) and wrinkles (4.63%), whereas the formula containing tea and rooibos showed the best efficacy on wrinkle reduction (9.9%). In comparison to the tea and rooibos formula, gingko significantly improved skin moisturization (P = 0.05).

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Consumer Behavior
  • Cosmetics / pharmacology*
  • Female
  • Flavonoids / pharmacology*
  • Humans
  • Middle Aged
  • Plant Extracts / pharmacology*
  • Single-Blind Method
  • Skin Aging / drug effects*
  • Surveys and Questionnaires


  • Cosmetics
  • Flavonoids
  • Plant Extracts