Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study

Int J Urol. 2010 Jun;17(6):548-54. doi: 10.1111/j.1442-2042.2010.02528.x. Epub 2010 Apr 19.


Objective: The aim of this study was to assess the efficacy and safety of two different types of medical mushrooms in patients with prostate cancer in Japan.

Methods: Patients with biochemical failure after radical treatment for non-metastasized prostate cancer were enrolled in this open-label study. For 6 months they ingested one of the two following supplements: Senseiro, containing extracts from the Agaricus blazei Murill mushroom; and Rokkaku Reishi, containing the Ganoderma lucidum mushroom. Levels of serum prostate-specific antigen (PSA) level and PSA doubling time were examined before and after study entry to assess the impact of these supplements on disease progression. The primary end-point of this study was partial response rate (50% or more decrease of serum PSA). Hormonal status, represented by serum testosterone levels, and toxicity were also assessed.

Results: A total of 51 patients were enrolled following radical prostatectomy. Forty-seven completed the protocol and could be assessed. Thirty-two patients received Senseiro and the remaining 15 received Rokkaku Reishi. No partial response in terms of PSA was observed. Alteration of PSA doubling time did not correlate with that of serum testosterone levels. Serious adverse effects were not observed.

Conclusions: No significant anticancer effects were observed with the intake of these two medical mushrooms.

MeSH terms

  • Agaricus*
  • Aged
  • Aged, 80 and over
  • Complementary Therapies*
  • Humans
  • Male
  • Middle Aged
  • Prostate-Specific Antigen / blood
  • Prostatectomy
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / surgery
  • Prostatic Neoplasms / therapy*
  • Reishi*
  • Treatment Failure


  • Prostate-Specific Antigen