Cardiorespiratory fitness and metabolic syndrome in older men and women: the dose responses to Exercise Training (DR's EXTRA) study

Diabetes Care. 2010 Jul;33(7):1655-7. doi: 10.2337/dc10-0124. Epub 2010 Apr 22.


Objective: We studied the association of maximum oxygen uptake (Vo(2max)) with the development and resolution of metabolic syndrome (MetS) for 2 years in older individuals.

Research design and methods: Subjects were a population sample of 1,226 men and women aged 57-78 years. We assessed Vo(2max) directly by respiratory gas analysis during maximum exercise testing and used dichotomous and continuous variables for MetS.

Results: One SD increase in baseline Vo(2max) associated with 44% (95% CI 24-58) decreased risk of developing MetS. Individuals in the highest third of baseline Vo(2max) were 68% (37-84) less likely to develop MetS than those in the lowest third. One SD increase in Vo(2max) increased the likelihood to resolve MetS 1.8 (1.2-2.8) times. Individuals in the highest Vo(2max) third were 3.9 (1.5-9.9) times more likely to resolve MetS than those in the lowest third.

Conclusions: Higher levels of cardiorespiratory fitness protect against MetS and may resolve it in older individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / physiology*
  • Blood Glucose / metabolism
  • Blood Pressure / physiology
  • Cholesterol, HDL / blood
  • Exercise / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Male
  • Metabolic Syndrome / physiopathology*
  • Metabolic Syndrome / prevention & control*
  • Middle Aged
  • Motor Activity / physiology*
  • Oxygen Consumption / physiology
  • Surveys and Questionnaires
  • Waist Circumference


  • Blood Glucose
  • Cholesterol, HDL

Associated data

  • ISRCTN/ISRCTN45977199