A BRCA1 promoter variant (rs11655505) and breast cancer risk

J Med Genet. 2010 Apr;47(4):268-70. doi: 10.1136/jmg.2009.073544.


Background: A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.

Methods: We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.

Results: No evidence for an association between rs11655505 and breast cancer risk was found.

Conclusions: Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • BRCA1 Protein / genetics
  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Female
  • Genes, BRCA1*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Logistic Models
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic


  • BRCA1 Protein
  • BRCA1 protein, human