IL-33 and IL-33 receptors in host defense and diseases

Allergol Int. 2010 Jun;59(2):143-60. doi: 10.2332/allergolint.10-RAI-0186. Epub 2010 Apr 24.

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Host-Pathogen Interactions
  • Humans
  • Hypersensitivity / genetics
  • Hypersensitivity / immunology*
  • Immunity
  • Infections / genetics
  • Infections / immunology*
  • Inflammation
  • Interleukin-1 Receptor-Like 1 Protein
  • Interleukin-33
  • Interleukins / immunology*
  • Mice
  • Polymorphism, Genetic
  • Receptors, Cell Surface / immunology
  • Receptors, Interleukin / immunology
  • Th2 Cells / immunology*
  • Toll-Like Receptors / immunology

Substances

  • IL1RL1 protein, human
  • IL33 protein, human
  • Il1rl1 protein, mouse
  • Interleukin-1 Receptor-Like 1 Protein
  • Interleukin-33
  • Interleukins
  • Receptors, Cell Surface
  • Receptors, Interleukin
  • Toll-Like Receptors