A case of severe MAGIC syndrome treated successfully with the tumor necrosis factor-alpha inhibitor infliximab

J Clin Rheumatol. 2010 Jun;16(4):185-7. doi: 10.1097/RHU.0b013e3181dfce16.

Abstract

We report a patient with an overlap of relapsing polychondritis and Behcet disease whose cartilaginous inflammation and genital lesions were refractory to corticosteroids and immunosuppressants, but fully remitted with the tumor necrosis factor-alpha inhibitor, infliximab. We believe this case represents the first report of a response to a tumor necrosis factor inhibitor in a patient with mouth and genital ulcerations with inflamed cartilage syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Behcet Syndrome / complications*
  • Behcet Syndrome / drug therapy*
  • Humans
  • Infliximab
  • Male
  • Polychondritis, Relapsing / complications*
  • Polychondritis, Relapsing / drug therapy*
  • Remission Induction
  • Syndrome
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Infliximab