Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

Nat Rev Cancer. 2010 May;10(5):319-31. doi: 10.1038/nrc2818.


Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis. This Review summarizes these developments in the context of the evolving notion of molecular pathology and discusses the implications that this work has on the design of new treatment regimens.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / classification
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Cerebellar Neoplasms / classification
  • Cerebellar Neoplasms / genetics*
  • Cerebellar Neoplasms / pathology
  • Glioma / classification
  • Glioma / genetics*
  • Glioma / pathology
  • Humans
  • Medulloblastoma / classification
  • Medulloblastoma / genetics*
  • Medulloblastoma / pathology
  • Pathology, Molecular / trends*