Abstract
The movement of microtubules on the kinetochores of isolated chromosomes has been examined by video microscopy. Two different microtubule-based motors on the kinetochore were identified, which have opposite directions of movement. The activities of these two motors can be regulated by factors that can influence phosphorylation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenine / analogs & derivatives
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Adenine / pharmacology
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Adenosine Triphosphate / analogs & derivatives
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Adenosine Triphosphate / pharmacology
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Adenosine Triphosphate / physiology
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Animals
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Cricetinae
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Microscopy, Fluorescence
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Microtubules / physiology*
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Mitosis / drug effects
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Phosphorylation / drug effects
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Spindle Apparatus / physiology*
Substances
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adenosine 5'-O-(3-thiotriphosphate)
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Adenosine Triphosphate
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Adenine
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6-methyladenine