Two different microtubule-based motor activities with opposite polarities in kinetochores

Nature. 1991 May 16;351(6323):206-11. doi: 10.1038/351206a0.

Abstract

The movement of microtubules on the kinetochores of isolated chromosomes has been examined by video microscopy. Two different microtubule-based motors on the kinetochore were identified, which have opposite directions of movement. The activities of these two motors can be regulated by factors that can influence phosphorylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / pharmacology
  • Adenosine Triphosphate / analogs & derivatives
  • Adenosine Triphosphate / pharmacology
  • Adenosine Triphosphate / physiology
  • Animals
  • Cricetinae
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Microscopy, Fluorescence
  • Microtubules / physiology*
  • Mitosis / drug effects
  • Phosphorylation / drug effects
  • Spindle Apparatus / physiology*

Substances

  • adenosine 5'-O-(3-thiotriphosphate)
  • Adenosine Triphosphate
  • Adenine
  • 6-methyladenine