Preclinical Parkinson's disease: detection of motor and nonmotor manifestations

Neurology. 1991 May;41(5 Suppl 2):69-71; discussion 72. doi: 10.1212/wnl.41.5_suppl_2.69.


The advent of possible protective therapies for Parkinson's disease has created a need for methods of diagnosing the disease before the clinical features become fully evident. As a number of motor and nonmotor manifestations of the disease emerge months to years before a diagnosis can be made, a battery of clinical tests might be sufficient to identify individuals at an earlier stage than is currently possible using the standard history and physical examination. A list of questions regarding possible risk factors, specific symptoms, and observations of family members could be combined in a self-administered questionnaire that might identify individuals with a high probability of early, but otherwise undiagnosable, Parkinson's disease. Identification of subtle motor features is another possible screening method. For example, handwriting and speech are commonly affected prior to diagnosis; thus, automated analysis of these motor actions might also provide detection of incipient disease.

Publication types

  • Duplicate Publication
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Handwriting
  • Humans
  • Movement Disorders / diagnosis*
  • Movement Disorders / etiology
  • Parkinson Disease / complications
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / psychology
  • Pilot Projects
  • Speech
  • Surveys and Questionnaires