Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI study

Clin Nutr. 2010 Oct;29(5):674-7. doi: 10.1016/j.clnu.2010.03.012. Epub 2010 Apr 22.


Background & aims: Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown.

Methods: Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy.

Results: Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2)ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β±SE: 43.76±11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β±SE: 36.7±12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β±SE: 40.1±12.0, p=0.0008).

Conclusions: We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Cross-Sectional Studies
  • Energy Intake
  • Female
  • Humans
  • Insulin-Like Growth Factor I / metabolism*
  • Italy
  • Male
  • Residence Characteristics
  • Selenium / blood*
  • Selenium / metabolism


  • Insulin-Like Growth Factor I
  • Selenium