Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides

Appl Environ Microbiol. 2010 Jul;76(13):4542-5. doi: 10.1128/AEM.02264-09. Epub 2010 Apr 23.

Abstract

Enterocin X, composed of two antibacterial peptides (Xalpha and Xbeta), is a novel class IIb bacteriocin from Enterococcus faecium KU-B5. When combined, Xalpha and Xbeta display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. In E. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / metabolism
  • Anti-Bacterial Agents* / pharmacology
  • Bacteria / drug effects
  • Bacteriocins / biosynthesis
  • Bacteriocins / chemistry
  • Bacteriocins / genetics
  • Bacteriocins / metabolism
  • Bacteriocins / pharmacology*
  • Base Sequence
  • Bridged-Ring Compounds / chemistry
  • Bridged-Ring Compounds / metabolism
  • Bridged-Ring Compounds / pharmacology
  • Drug Antagonism
  • Drug Synergism
  • Enterococcus faecium / genetics
  • Enterococcus faecium / growth & development
  • Enterococcus faecium / metabolism
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Peptides / chemistry
  • Peptides / metabolism
  • Peptides / pharmacology*
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Bacteriocins
  • Bridged-Ring Compounds
  • Peptides
  • enterocin A
  • enterocin B
  • enterocin

Associated data

  • GENBANK/AB292463
  • GENBANK/AB292464
  • GENBANK/AB430879