Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 17 (3), 155-61

New Insights Into Merkel Cell Carcinoma


New Insights Into Merkel Cell Carcinoma

Kenneth B Calder et al. Adv Anat Pathol.


Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine and epithelial differentiation. Recently, the Merkel cell polyomavirus has been implicated in the pathogenesis of MCC. In addition, there have been numerous studies evaluating the histologic and immunohistochemical characteristics of MCC as they relate to diagnosis and prognosis. The purpose of this paper is to review the most salient and clinically relevant updates in the pathogenesis and histologic features of MCC. Specific attention is given to the clinical and histologic predictors of prognosis, staging, and the controversies concerning sentinel lymph node biopsy and therapy.

Comment in

Similar articles

  • Merkel cell carcinoma.
    Han SY, North JP, Canavan T, Kim N, Yu SS. Han SY, et al. Hematol Oncol Clin North Am. 2012 Dec;26(6):1351-74. doi: 10.1016/j.hoc.2012.08.007. Epub 2012 Oct 9. Hematol Oncol Clin North Am. 2012. PMID: 23116583 Review.
  • Merkel cell carcinoma: review.
    Pulitzer MP, Amin BD, Busam KJ. Pulitzer MP, et al. Adv Anat Pathol. 2009 May;16(3):135-44. doi: 10.1097/PAP.0b013e3181a12f5a. Adv Anat Pathol. 2009. PMID: 19395876 Review.
  • Merkel cell carcinoma.
    Swann MH, Yoon J. Swann MH, et al. Semin Oncol. 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. Semin Oncol. 2007. PMID: 17270666 Review.
  • Merkel cell carcinoma of the head and neck.
    Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A. Suárez C, et al. Oral Oncol. 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. Oral Oncol. 2004. PMID: 15288830 Review.
  • Merkel cell carcinoma--pathogenesis, clinical aspects and treatment.
    Schrama D, Becker JC. Schrama D, et al. J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1121-9. doi: 10.1111/j.1468-3083.2011.04032.x. J Eur Acad Dermatol Venereol. 2011. PMID: 21923810
See all similar articles

Cited by 17 articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources