This study describes and tests two models of personality: the HEXACO model of personality, which is derived from the lexical tradition and which is rooted in "normal" psychology, and the 5DPT model of personality, which is derived from a theoretical approach and which is rooted in clinical psychology. The HEXACO and 5DPT models are compared in the prediction of antisocial and self-benefiting personality traits in a large-scale community sample study. Relative weight analyses show that HEXACO Honesty-Humility explains most of the variance in SRPIII Psychopathy, Egoism, and IPIP Pretentiousness, Immorality, and Machiavellianism. Additionally, Honesty-Humility is able to increment the amount of variance explained by the 5DPT scales in these antisocial and self-benefiting personality scales. Consequences for the 5DPT and for the choice of a dimensional axis-II personality model in the run-up of the DSM-V are discussed.