Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases

Clin Infect Dis. 2010 Jun 1;50(11):e63-8. doi: 10.1086/652656.


We describe 3 cases of daptomycin-induced pulmonary toxic effects that are consistent with drug-induced acute eosinophilic pneumonia. Patients presented similarly with dyspnea, cough, hypoxia, and diffuse ground-glass opacities at chest computed tomography. Clinical suspicion for this adverse drug event and cessation of daptomycin until definitive diagnosis can be made is crucial.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / adverse effects*
  • Daptomycin / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / diagnosis*
  • Pulmonary Eosinophilia / pathology
  • Radiography, Thoracic
  • Tomography


  • Anti-Bacterial Agents
  • Daptomycin