This paper illustrates two extensive applications of a smart garment we previously developed for the monitoring of ECG, respiration, and movement. In the first application, the device, named Maglietta Interattiva Computerizzata (MagIC), was used for the home monitoring of cardiac patients. The used platform included MagIC for signals collection, a touchscreen computer with a dedicated software for data handling, and a universal mobile telecommunications system (UMTS) dongle for data transmission, via email, to three cardiologists. Three patients daily-performed 3-min telemonitoring sessions for 30 days by using the platform. The whole system behaved correctly in 85 out of 90 sessions. In five instances, a second session was required due to UMTS traffic congestion. Only in three sessions, cardiologists asked the patient to repeat the acquisition because of poor signal quality. In the second application, MagIC was used to evaluate the effects of high-altitude hypoxia on sleep and 24 h daily life in 30 healthy subjects at 3500 and 5400 m above sea level on Mount Everest slopes. The use of MagIC garment was reported to be simple and requiring short instrumentation time even in the demanding expedition environment. The signal quality was adequate in 111 out of 115 recordings and 90% of the subjects found the vest comfortable.