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. 2010 Aug;33(8):1699-705.
doi: 10.2337/dc09-2302. Epub 2010 Apr 27.

Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

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Free PMC article

Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

Joline W J Beulens et al. Diabetes Care. .
Free PMC article

Abstract

Objective: To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.

Research design and methods: We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records.

Results: During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-microg increment in the multivariate model.

Conclusions: This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.

Figures

Figure 1
Figure 1
Association between phylloquinone intake and risk of type 2 diabetes modeled continuously using splines; HR (——) with 95% CI in gray.

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