Can antihypertensive treatment reverse large-artery stiffening?

Curr Hypertens Rep. 2010 Feb;12(1):47-51. doi: 10.1007/s11906-009-0085-7.


In some controlled therapeutic trials for hypertension, a selective reduction of systolic blood pressure has been obtained with long-term treatment. The greatest effects on cardiovascular outcomes stem from a decrease of central blood pressure through a significant reduction of arterial stiffness, wave reflections, or both. Until now, all protocols have used angiotensin II blockade, mainly through angiotensin-converting enzyme inhibition. Cardiovascular outcomes have been significantly improved when compared with controls, but most of them have been treated with beta blockers. Such "de-stiffening" therapies are important to consider and require additional trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Arteries / drug effects*
  • Arteries / physiopathology*
  • Blood Pressure / physiology*
  • Calcium Channel Blockers / therapeutic use
  • Cardiovascular Diseases / prevention & control
  • Elasticity
  • Humans
  • Hypertension / drug therapy*
  • Pulse


  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Calcium Channel Blockers