Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul;12(4):273-81.
doi: 10.1007/s11883-010-0110-y.

Lipidomics: A Tool for Studies of Atherosclerosis

Affiliations
Free PMC article

Lipidomics: A Tool for Studies of Atherosclerosis

Kim Ekroos et al. Curr Atheroscler Rep. .
Free PMC article

Abstract

Lipids, abundant constituents of both the vascular plaque and lipoproteins, play a pivotal role in atherosclerosis. Mass spectrometry-based analysis of lipids, called lipidomics, presents a number of opportunities not only for understanding the cellular processes in health and disease but also in enabling personalized medicine. Lipidomics in its most advanced form is able to quantify hundreds of different molecular lipid species with various structural and functional roles. Unraveling this complexity will improve our understanding of diseases such as atherosclerosis at a level of detail not attainable with classical analytical methods. Improved patient selection, biomarkers for gauging treatment efficacy and safety, and translational models will be facilitated by the lipidomic deliverables. Importantly, lipid-based biomarkers and targets should lead the way as we progress toward more specialized therapeutics.

Figures

Fig. 1
Fig. 1
Lipidomic analysis conducted on human left internal mammary artery and rat aorta samples show distinct species-specific composition. CE—cholesteryl esters; DAG—diacylglycerols; PC—phosphatidylcholines; PE—phosphatidylethanolamines; PS—phosphatidylserines; SM—sphingomyelins

Similar articles

See all similar articles

Cited by 27 articles

See all "Cited by" articles

References

    1. • Ejsing CS, Sampaio JL, Surendranath V, et al.: Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci U S A 2009, 106:2136–2141. This is a comprehensive and pioneering work on the yeast lipidome, showing the road forward for lipidomics. - PMC - PubMed
    1. Stahlman M, Ejsing CS, Tarasov K, et al.: High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877:2664–2772. - PubMed
    1. Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res. 2003;44:1071–1079. doi: 10.1194/jlr.R300004-JLR200. - DOI - PubMed
    1. Yetukuri L, Ekroos K, Vidal-Puig A, et al. Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008;4:121–127. doi: 10.1039/b715468b. - DOI - PubMed
    1. Meer G. Cellular lipidomics. EMBO J. 2005;24:3159–3165. doi: 10.1038/sj.emboj.7600798. - DOI - PMC - PubMed

LinkOut - more resources

Feedback