Theories of the pathogenesis of inclusion body myositis

Curr Rheumatol Rep. 2010 Jun;12(3):221-8. doi: 10.1007/s11926-010-0102-5.


Inclusion body myositis is a progressive disease of the skeletal muscle. Here, specific theories of its pathogenesis are reviewed and general considerations pertaining to modeling of this disease discussed. Understanding of inclusion body myositis disease mechanism remains extremely poor. Current published animal models do not represent the disease. Future studies need to consider the critical role of biomarkers and methodologic issues in their discovery.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Disease Models, Animal
  • Humans
  • Muscle Fibers, Skeletal / metabolism
  • Muscle Fibers, Skeletal / pathology
  • Myositis, Inclusion Body / etiology*
  • Myositis, Inclusion Body / metabolism
  • Myositis, Inclusion Body / pathology
  • Skin / metabolism
  • Skin / pathology


  • Biomarkers