Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves

Vet Ther. Winter 2009;10(4):E1-18.

Abstract

In this field trial, a new combination product containing florfenicol and flunixin meglumine (FLOR-FM) was compared with commercially available products that contained only tulathromycin (TULA) or ceftiofur crystalline free acid (CCFA) for the treatment of undifferentiated fever (UF; rectal temperature >/=105.0 degrees F) in beef calves that received long-acting oxytetracycline at feedlot arrival. The overall mortality rate of the FLOR FM group (2.0%) was significantly (P less than .050) lower than the rates in the TULA and CCFA groups (10.0% and 20.0%, respectively; 50 animals/group), even though the first UF relapse rate of the FLOR FM group was significantly (P less than .050) higher than that of the TULA group. In the FLOR FM group, this resulted in per-animal economic advantages of Can$46.23 (versus TULA) and Can$108.77 (versus CCFA) based on equal costs for initial UF therapy. These results demonstrate that it is more cost-effective to administer FLOR FM than TULA or CCFA for initial UF therapy in feedlot calves at high risk for bovine respiratory disease that receive metaphylactic long-acting oxytetracycline at feedlot arrival.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Cattle
  • Cattle Diseases / drug therapy*
  • Cephalosporins / therapeutic use*
  • Clonixin / administration & dosage
  • Clonixin / analogs & derivatives*
  • Clonixin / therapeutic use
  • Disaccharides / therapeutic use*
  • Drug Combinations
  • Fever / drug therapy
  • Fever / veterinary*
  • Heterocyclic Compounds / therapeutic use*
  • Housing, Animal
  • Thiamphenicol / administration & dosage
  • Thiamphenicol / analogs & derivatives*
  • Thiamphenicol / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cephalosporins
  • Disaccharides
  • Drug Combinations
  • Heterocyclic Compounds
  • ceftiofur
  • flunixin meglumine
  • florfenicol
  • Thiamphenicol
  • tulathromycin
  • Clonixin