Role of PD-1 in regulating acute infections

Curr Opin Immunol. 2010 Jun;22(3):397-401. doi: 10.1016/j.coi.2010.03.007. Epub 2010 Apr 27.


While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Antigens, Differentiation / metabolism*
  • Cell Differentiation
  • Gene Expression Regulation / immunology*
  • Humans
  • Immunologic Memory
  • Infections / etiology
  • Infections / immunology*
  • Infections / metabolism
  • Lymphocyte Activation
  • Mice
  • Programmed Cell Death 1 Receptor
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism


  • Antigens, Differentiation
  • Pdcd1 protein, mouse
  • Programmed Cell Death 1 Receptor