Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways

Leukemia. 2010 Jun;24(6):1216-20. doi: 10.1038/leu.2010.73. Epub 2010 Apr 29.

Authors

A Kohlmann, L Bullinger, C Thiede, M Schaich, S Schnittger, K Döhner, M Dugas, H-U Klein, H Döhner, G Ehninger, T Haferlach

PMID: 20428199
DOI: 10.1038/leu.2010.73

No abstract available

Publication types

Letter

MeSH terms

Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Blotting, Western
CCAAT-Enhancer-Binding Proteins / genetics
Gene Expression Profiling*
Humans
Karyotyping
Leukemia, Myeloid, Acute / classification*
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism
Mutation / genetics*
Nuclear Proteins / genetics
Nucleophosmin
Oligonucleotide Array Sequence Analysis
Predictive Value of Tests
RNA, Messenger / genetics
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Risk Assessment
Signal Transduction*
fms-Like Tyrosine Kinase 3 / genetics

Substances

Biomarkers, Tumor
CCAAT-Enhancer-Binding Proteins
CEBPA protein, human
Nuclear Proteins
RNA, Messenger
Nucleophosmin
FLT3 protein, human
fms-Like Tyrosine Kinase 3