Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives

Synlett. 2008 Jun 1;2008(10):1510-1514. doi: 10.1055/s-2007-1077795.

Abstract

We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.