Counting algorithms for linkage: correction to Morton and Collins

Ann Hum Genet. 1991 Jan;55(1):33-8. doi: 10.1111/j.1469-1809.1991.tb00395.x.

Abstract

In a recent paper, Morton & Collins (1990) claimed: (1) that the Lander-Green algorithm for genetic linkage analysis is not the EM algorithm for finding the maximum likelihood map; and (2) that a proposed alternative algorithm does have these properties. Here, we show that these assertions are both incorrect: the Lander-Green algorithm is an EM algorithm, while the Morton-Collins algorithm is not. We note that Morton and Collins concur with these conclusions.

Publication types

  • Comment

MeSH terms

  • Algorithms*
  • Genetic Linkage*