Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases

Scand J Infect Dis. 2010 Aug;42(8):634-6. doi: 10.3109/00365541003754477.

Abstract

We report 3 cases of disease - leptospirosis, tropical malaria and fulminant meningococcaemia - associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability. Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antimicrobial Cationic Peptides / blood*
  • Bacteremia / complications
  • Biomarkers
  • Blood Proteins
  • Carrier Proteins / blood*
  • Female
  • Humans
  • Malaria / complications
  • Male
  • Middle Aged
  • Sepsis / complications*
  • Shock / diagnosis*

Substances

  • AZU1 protein, human
  • Antimicrobial Cationic Peptides
  • Biomarkers
  • Blood Proteins
  • Carrier Proteins