Amyloid detection is very precise at this time, because several methods are available to the pathologist. Awareness of potential nonspecific staining, possible pitfalls and methods for improving the detection process are basic to enhancing the staining of amyloid and interpreting this staining. The role of the pathologist has progressed through history from the basic detection of amyloid as a substance to immunophenotypical classification of the particular amyloid present.