Euprolactinemic galactorrhea associated with use of imipramine and escitalopram in a postmenopausal woman

Gen Hosp Psychiatry. 2010 May-Jun;32(3):341.e11-3. doi: 10.1016/j.genhosppsych.2009.07.006. Epub 2009 Aug 27.


Hormonal side effects of antidepressants are infrequent, and galactorrhea is seldom mentioned among tricyclic antidepressant (TCA) and selective serotonin reuptake inhibitor (SSRI)-related side effects. Antidepressants can directly stimulate postsynaptic 5-HT receptors in the hypothalamus or indirectly inhibit the tuberoinfundibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. We describe a case of euprolactinemic galactorrhea in a postmenopausal woman, induced by imipramine and escitalopram. This report highlights the presence of unidentified novel mechanisms of antidepressant-induced galactorrhea and other possible contributors.

MeSH terms

  • Antidepressive Agents, Second-Generation / adverse effects*
  • Antidepressive Agents, Tricyclic / adverse effects*
  • Citalopram / adverse effects*
  • Female
  • Galactorrhea / chemically induced*
  • Humans
  • Hyperprolactinemia / blood
  • Hyperprolactinemia / chemically induced*
  • Hyperprolactinemia / complications
  • Imipramine / adverse effects*
  • Middle Aged
  • Postmenopause / psychology


  • Antidepressive Agents, Second-Generation
  • Antidepressive Agents, Tricyclic
  • Citalopram
  • Imipramine