A possible case of mixed mania due to neurosarcoidosis treated successfully with methylprednisolone and ziprasidone: another example of frontal-subcortical disinhibition?

Gen Hosp Psychiatry. May-Jun 2010;32(3):342.e1-3. doi: 10.1016/j.genhosppsych.2009.07.010. Epub 2009 Sep 11.

Abstract

Sarcoidosis is an idiopathic systemic granulomatous disease recognized by clinical and radiographic findings, which ultimately require histopathologic confirmation of noncaseating granulomas for a definitive diagnosis. Psychiatric manifestations occur in 20% of patient with neurosarcoidosis [http://dynaweb.ebscohost.com.chekov.evms.edu/Detail.aspx?id=306337&sid=bdce39cc-d2bd-4977-9e4d-786f2e768d57@sessionmgr4]. We present a case of suspected mixed mania due to neurosarcoidosis, with the manic symptoms responding early and robustly to ziprasidone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • African Americans
  • Anti-Inflammatory Agents / therapeutic use*
  • Antipsychotic Agents / therapeutic use*
  • Bipolar Disorder / etiology*
  • Bipolar Disorder / physiopathology
  • Cerebral Cortex / physiopathology
  • Female
  • Humans
  • Methylprednisolone / therapeutic use*
  • Piperazines / therapeutic use*
  • Sarcoidosis / complications
  • Sarcoidosis / drug therapy*
  • Thiazoles / therapeutic use*
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Antipsychotic Agents
  • Piperazines
  • Thiazoles
  • ziprasidone
  • Methylprednisolone