Hyperoxia-derived lung damage in preterm infants

Semin Fetal Neonatal Med. 2010 Aug;15(4):223-9. doi: 10.1016/j.siny.2010.03.009. Epub 2010 Apr 28.


Hyperoxia-induced lung injury is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. This review highlights the mechanistic aspects of inflammation, vascular leak and cell death. The focus will be on agents that contribute to hyperoxia-induced lung injury in developmentally appropriate animal models, and those that have been detected in human premature neonates.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Hyperoxia / metabolism
  • Hyperoxia / pathology*
  • Infant, Newborn
  • Infant, Premature / metabolism*
  • Lung Injury / metabolism
  • Lung Injury / pathology*