Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 3 (2), 95-100

Prevalence of Subjects at a High or Very High Risk of Gastric Cancer in Japan

Affiliations

Prevalence of Subjects at a High or Very High Risk of Gastric Cancer in Japan

Miyoko Yamaoka et al. Gut Liver.

Abstract

Background/aims: The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To determine the prevalence of subjects at a high risk (HpSA+ or PG+) or very high risk (PG+) of gastric cancer in Japan, we applied the two tests to a general population.

Methods: The subjects included 311 volunteers. We used Meridian HpSA ELISA for the HpSA test and Pepsinogen RIA Beads for the PG test. PG I at </=70 microg/L and I/II ratio of </=3.0 were used as cutoffs for PG-test positivity.

Results: Positivity rates in HpSA and PG tests significantly increased with age in those younger than 60 years and in all age groups, respectively. The proportions of HpSA-/PG- and HpSA+/PG+ sujects decreased and increased with age, respectively. A small proportion of HpSA-/PG+ subjects were older than 40 years. The prevalence of subjects who were either HpSA+ or PG+ increased with age (>50% of those older than 40 years). Half of the subjects older than 60 years were PG+.

Conclusions: In Japan, more than 50% of general population aged >/=40 years is at a high risk of gastric cancer, and half of the population aged >/=60 years is at a very high risk.

Keywords: Epidemiology; Gastric cancer screening; Helicobacter pylori; Pepsinogen; Stool antigen.

Figures

Fig. 1
Fig. 1
Age and sex distributions of the study subjects. Age distribution of the study subjects differed significantly with sex (chi-square test, p=0.000274).
Fig. 2
Fig. 2
Positive rate in the HpSA test for each sex (A) and across all subjects (B) according to age groups. HpSA positivity differed significantly with sex only in those aged 50-59 years (Yates' corrected chi-square test, p=0.034). The positive rate in the HpSA test was significantly correlated with age in males <60 years old and in all age groups in females (Spearman's correlation test: rs=1, p<0.0001). The positive rate in the HpSA test was significantly correlated with age in combined males and females younger than 60 years (Spearman's correlation test: rs=1, p<0.0001).
Fig. 3
Fig. 3
Positive rate in the PG test for each sex (A) and across all subjects (B) according to age groups. PG positivity did not differ significantly with sex (Yates' corrected chi-square test). PG positivity was significantly correlated with age for each sex (A) and across all subjects (B) (Spearman's correlation test: rs=1, p<0.0001).
Fig. 4
Fig. 4
Proportion of the results of HpSA and PG tests for males (A), females (B) and all subjects (C) according to age groups. The proportion of the two test results did not differ significantly with sex in each age group (Yates' corrected chi-square test).

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

References

    1. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–789. - PubMed
    1. Ohata H, Kitauchi S, Yoshimura N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 2004;109:138–143. - PubMed
    1. Ohkura R, Miwa H, Murai T, et al. Usefulness of a novel enzyme immunoassay for the detection of Helicobacter pylori in feces. Scand J Gastroenterol. 2000;35:49–53. - PubMed
    1. Oishi Y, Kiyohara Y, Kubo M, et al. The serum pepsinogen test as a predictor of gastric cancer: the Hisayama Study. Am J Epidemiol. 2006;163:629–637. - PubMed
    1. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992;52:6735–6740. - PubMed

LinkOut - more resources

Feedback