On-resin dimerization incorporates a diverse array of pi-conjugated functionality within aqueous self-assembling peptide backbones

Geeta S Vadehra; Brian D Wall; Stephen R Diegelmann; John D Tovar

doi:10.1039/c0cc00301h

On-resin dimerization incorporates a diverse array of pi-conjugated functionality within aqueous self-assembling peptide backbones

Chem Commun (Camb). 2010 Jun 14;46(22):3947-9. doi: 10.1039/c0cc00301h. Epub 2010 Apr 29.

Authors

Geeta S Vadehra¹, Brian D Wall, Stephen R Diegelmann, John D Tovar

Affiliation

¹ Department of Chemistry, Johns Hopkins University, 3400 N. Charles St. (NCB 316), Baltimore, MD 21218, USA.

PMID: 20431818
DOI: 10.1039/c0cc00301h

Abstract

We report a convenient method to incorporate pi-electron units into peptides that assemble into amyloid-like supramolecular polymers, discussing the scope of the process and preliminary characterization of the resulting nanomaterials. Self-assembly manipulates these "electronic peptides" into delocalized sub-10 nm 1-D nanostructures under completely aqueous conditions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Dimerization
Electrons
Hydrogen-Ion Concentration
Immobilized Proteins / chemistry
Nanostructures / chemistry
Peptides / chemistry*
Protein Structure, Secondary
Water / chemistry

Substances

Immobilized Proteins
Peptides
Water