Sexual quality of life of individuals with disorders of sex development and a 46,XY karyotype: a review of international research

J Sex Marital Ther. 2010;36(3):193-215. doi: 10.1080/00926231003719574.


This article summarizes the current state of research on Sexual Quality of Life (SexQoL) of adults with 46,XY Disorders of Sex Development (DSD)/Intersexuality. An extensive literature search yield 21 studies published between 1974-2007, examining sexual aspects in individuals with 46,XY DSD. However, many of them lack methodological quality. The results are inconsistent but overall indicate that SexQoL of individuals with 46,XY DSD is impaired, particular with regard to sexual dysfunctions and sexual satisfaction. Future studies on SexQoL should focus more on qualitative aspects of sexuality and investigate medical and psychosocial risk factors such as sex-corrective surgery and parental bonding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Chromosomes, Human, X / genetics
  • Chromosomes, Human, Y / genetics
  • Disorders of Sex Development / genetics
  • Disorders of Sex Development / psychology*
  • Gonadal Dysgenesis, 46,XY / diagnosis
  • Gonadal Dysgenesis, 46,XY / genetics
  • Gonadal Dysgenesis, 46,XY / psychology*
  • Gonadal Dysgenesis, 46,XY / therapy
  • Humans
  • Karyotyping
  • Male
  • Quality of Life / psychology*
  • Research
  • Sexual Behavior / psychology*