Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology

J Cell Physiol. 2010 Sep;224(3):605-11. doi: 10.1002/jcp.22183.

Abstract

The biology of cross-talk between activated growth factor receptors and cell-surface integrins is an area which has attracted much interest in recent years (Schwartz and Ginsberg, 2002). This review discusses the relationship between the insulin-like growth factor (IGF) axis and cell-surface integrin receptors in the regulation of various aspects of cell physiology. Key to these interactions are signals transmitted between integrins and the IGF-I receptor (IGF-IR) when either or both are bound to their cognate ligands and we will review the current state of knowledge in this area. The IGF axis comprises many molecular components and we will also discuss the potential role of these species in cross-talk with the integrin receptor. With respect to integrin ligands, we will mainly focus on the well-characterized interactions of the two extracellular matrix (ECM) glycoproteins fibronectin (FN) and vitronectin (VN) with cell-surface ligands, and, how this affects activity through the IGF axis. However, we will also highlight the importance of other integrin activation mechanisms and their impact on IGF activity.

Publication types

  • Review

MeSH terms

  • Cell Physiological Phenomena*
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / metabolism
  • Fibronectins / chemistry
  • Fibronectins / metabolism
  • Insulin-Like Growth Factor Binding Proteins / metabolism
  • Insulin-Like Growth Factor I / metabolism*
  • Integrins / genetics
  • Integrins / metabolism*
  • Protein Binding
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Receptor, IGF Type 1 / metabolism*
  • Signal Transduction / physiology*
  • Vitronectin / chemistry
  • Vitronectin / metabolism

Substances

  • Fibronectins
  • Insulin-Like Growth Factor Binding Proteins
  • Integrins
  • Protein Isoforms
  • Vitronectin
  • Insulin-Like Growth Factor I
  • integrin-linked kinase
  • Receptor, IGF Type 1
  • Protein-Serine-Threonine Kinases