Growth velocity in constitutional delay of growth and development

J Pediatr Endocrinol Metab. Jan-Feb 2010;23(1-2):19-25. doi: 10.1515/jpem.2010.23.1-2.19.


Growth velocity was determined in 121 boys and 58 girls with constitutional delay of growth and development (CDGD) of familial origin. No data were included from patients suffering from growth hormone insufficiency (i.e. neurosecretory dysfunction for growth hormone) or any disease. From 479 values obtained in boys and 230 values obtained in girls the 25th, 50th and 75th percentiles were calculated. The mean growth velocity in children and adolescents with CDGD before the beginning of puberty was lower than the mean growth velocity of other European (British, German or Swiss) standards.

Conclusion: Specific data of growth velocity should be used in patients with CDGD since population-based data may underestimate the normal growth velocity of these patients.

MeSH terms

  • Adolescent
  • Age Factors
  • Body Height
  • Child
  • Child, Preschool
  • Europe
  • Female
  • Growth / physiology*
  • Growth Charts*
  • Growth Disorders / diagnosis*
  • Growth Disorders / physiopathology*
  • Guidelines as Topic
  • Humans
  • Infant
  • Male
  • Puberty / physiology*
  • Reference Standards
  • Sex Factors
  • Young Adult