Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice
- PMID: 20433064
Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice
Abstract
trans-Dehydrocrotonin (t-DCTN), the diterpenoid from Croton cajucara Bentham, exhibits hypoglycemic and hypolipidemic activities, but in high doses is associated with a discrete hepatotoxicity. In the search for measures to mitigate this, pretreatment with the antioxidants N-acetylcysteine and vitamin E has been examined. Mice that received a high dose t-DCTN (100 mg/kg) manifested hepatic damage, as evidenced by significant elevations in serum ALT and AST, and hepatic GSH, and histological alterations, which could be obliterated by pretreatment with vitamin E, but not with N-acetylcysteine, possibly by creating an effective antioxidant balance.
Similar articles
-
A comparative study of the antioxidant properties of two different species of Ocimum of southern Africa on alcohol-induced oxidative stress.J Med Food. 2009 Oct;12(5):1154-8. doi: 10.1089/jmf.2008.0066. J Med Food. 2009. PMID: 19857083
-
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.Int Immunopharmacol. 2015 Dec;29(2):722-729. doi: 10.1016/j.intimp.2015.09.003. Epub 2015 Sep 9. Int Immunopharmacol. 2015. PMID: 26362205
-
Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats.Chem Biol Interact. 2008 May 28;173(2):77-83. doi: 10.1016/j.cbi.2008.02.010. Epub 2008 Mar 6. Chem Biol Interact. 2008. PMID: 18405891
-
Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice.Toxicology. 2008 Oct 30;252(1-3):86-91. doi: 10.1016/j.tox.2008.07.062. Epub 2008 Aug 7. Toxicology. 2008. PMID: 18755235
-
Croton cajucara: Patents and Nanotechnological Advances.Recent Pat Nanotechnol. 2024;18(4):389-394. doi: 10.2174/1872210517666230816090220. Recent Pat Nanotechnol. 2024. PMID: 37587801 Review.
Cited by
-
Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions.Front Pharmacol. 2014 Jul 9;5:162. doi: 10.3389/fphar.2014.00162. eCollection 2014. Front Pharmacol. 2014. PMID: 25071580 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical