Abstract
Two new angucyclines, saccharothrixmicines A (2) and B (3), together with three known diketopiperazines 4-6 were isolated from the actinomycete Saccharothrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni. Their structures were determined by HRESI-MS and 1D and 2D NMR. Compounds 2 and 3 differ in aglycone and glycosidic bond type. 2 is an alpha-L-6-deoxyaltrose-phenylglycoside of a benz[a]anthraquinone aglycone, while 3 is an O-glycoside of the same sugar linked to C-7 of the known angucyclinone (1). A saccharothrixmicine-containing fraction exhibited activity towards Candida albicans and Xanthomonas sp. pv. badrii whereas the diketopiperazines showed antibiotic activities against Vibrio alginolyticus and Vibrio parahaemolyticus.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Actinobacteria / chemistry*
-
Animals
-
Anthraquinones / chemistry
-
Anthraquinones / isolation & purification*
-
Anthraquinones / pharmacology
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology
-
Antifungal Agents / chemistry
-
Antifungal Agents / isolation & purification*
-
Antifungal Agents / pharmacology
-
Diketopiperazines / chemistry
-
Diketopiperazines / isolation & purification*
-
Diketopiperazines / pharmacology
-
Microbial Sensitivity Tests
-
Mollusca / microbiology*
-
Nuclear Magnetic Resonance, Biomolecular
-
Optical Rotation
-
Spectrometry, Mass, Electrospray Ionization
-
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
Substances
-
Anthraquinones
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Diketopiperazines