Emerging roles of PDGF-D signaling pathway in tumor development and progression

Biochim Biophys Acta. 2010 Aug;1806(1):122-30. doi: 10.1016/j.bbcan.2010.04.003. Epub 2010 Apr 28.

Abstract

Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring "chemopreventive agent" such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Survival
  • Disease Progression
  • Epithelial Cells / pathology
  • Humans
  • Interleukin-1beta / physiology
  • Lymphokines / physiology*
  • Mesoderm / pathology
  • MicroRNAs / physiology
  • Neoplasms / etiology*
  • Neoplasms / pathology
  • Platelet-Derived Growth Factor / physiology*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / physiology*
  • Urokinase-Type Plasminogen Activator / physiology

Substances

  • Interleukin-1beta
  • Lymphokines
  • MicroRNAs
  • PDGFD protein, human
  • Platelet-Derived Growth Factor
  • Reactive Oxygen Species
  • Urokinase-Type Plasminogen Activator